Copper(I)‐Catalyzed Decarboxylative N‐Phosphorylation: Modular Preparation of N‐Acyl Iminophosphoranes Using Dioxazolones and Phosphines

Abstract

AbstractDioxazolones and phosphines have been used to access N‐acyl iminophosphoranes in copper(I) catalysis under simple thermal conditions. The synthetic utility of this protocol is demonstrated by a broad range of substrates with an excellent atom‐economy. The optimization process showed that copper demonstrated as catalytic amount toward the targeted transformation. Functionalization studies of N‐acyl iminophosphoranes were also conducted. Our reaction protocol is compatible with an example of a bioactive motif‐containing N‐acyl iminophosphorane analogue.