Copper(I)‐Catalyzed [4+2] Oxidative Annulation of α,β‐Unsaturated Ketoxime Acetates with Cyclopropanols toward Functional Pyridines

Abstract

AbstractA Cu(I)‐catalyzed [4+2] oxidative annulation of α,β‐unsaturated ketoxime acetates with cyclopropanols has been developed for the synthesis of 2,4,5‐trisubstituted pyridines in 28–76% yields. This method employs cyclopropanols as C2 synthons and features various functional group compatibility and gram‐scale synthesis. In addition, a plausible reaction pathway was proposed based on the mechanism studies.