Affiliation:
1. PSL University, C himie ParisTech CNRS UMR 8060 Institute of Chemistry for Life and Health Sciences CSB2D Team 75005 Paris France
2. SEQENS, 2-8 rue de Rouen ZI de Limay-Porcheville 78440 Porcheville France
Abstract
AbstractWe report a process to access a variety of enantioenriched α‐gem‐difluorinated alcohols. A Rh(III)‐catalyzed asymmetric transfer hydrogenation method was developed in 85–98% yields and enantiomeric excesses ranging from 52% to >99%. The reduction proceeds under mild conditions with a range of difluorinated molecules including 3,3‐difluorochromanone, 3,3‐difluorothiochromanone, 3,3‐difluoro‐dihydroquinolinone and α‐difluorinated β‐ketosulfone derivatives to provide the desired enantioenriched difluorinated alcohols which are valuable fluorinated building blocks.
Cited by
2 articles.
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