Aza‐Prins Cyclization on Ketones to Access Piperidines with Tetrasubstituted Carbon Stereocenters

Abstract

AbstractThe aza‐Prins cyclization in presence of a variety of aliphatic, aromatic, and heterocyclic ketones is disclosed. The developed method allows an access to diverse C‐2 functionalized piperidines, bearing a tetrasubstituted or spiranic carbon stereocenter, in a range of 30 to 87% yields. When diastereomers were formed, the trans isomer was identified as the major product.