Affiliation:
1. National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and Health College of Chemistry Central China Normal University Wuhan 430079 People's Republic of China
2. State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 People's Republic of China
Abstract
AbstractA multicomponent cascade cyclization reaction using aryl methyl ketones, aryl amines, and enaminamide reagents to construct 3‐hydroxy‐1H‐pyrrolo[3,4‐b]quinolin‐1‐one skeleton with good substrate compatibility (50 examples) has been reported. The one‐pot, metal‐free process formed two C−C bonds, two C−N bonds, and a tetrasubstituted carbon stereocenter containing a hydroxyl group. The reaction enabled modified transformation of drug molecules and derivatization of products.
Funder
National Natural Science Foundation of China