Affiliation:
1. Technical Institute of Fluorochemistry Institute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University Nanjing 211816 People's Republic of China
2. Department of Chemistry and Materials Science College of Science Nanjing Forestry University Nanjing 210037 People's Republic of China
Abstract
AbstractThe distinctive hydrophobic hydration effect in the aqueous solution contributes to the success of the phospha‐Michael reaction between β‐CF3‐β,β‐disubstituted enones and diarylphosphine oxides, providing an access to biologically relevant γ‐ketophosphine oxides bearing a sterically highly congested CF3‐ and P(O)‐tetrasubstituted carbon center. More importantly, the resulting products could be further transformed into densely functionalized γ‐ketophosphine oxides containing a CF3‐ and P(O)‐tetrasubstituted carbon center.
Funder
National Natural Science Foundation of China
Nanjing Tech University
Cited by
1 articles.
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