Affiliation:
1. Key Laboratory of Applied Chemistry of Chongqing Municipality School of Chemistry and Chemical Engineering Southwest University Chongqing 400715 People's Republic of China
Abstract
AbstractA synthetic protocol for construction of 3‐benzoxepin skeleton through a silver‐catalyzed annulation/nucleophilic/ring‐expansion reaction of 2‐alkynylacetophenones with diazomethylphosphonates is described. This protocol provided a series of 1‐phosphonate‐3‐benzoxepin analogs in yields of 39%–95%. The resulting benzoxepins featuring halogen and phosphonate could be further transformed into other derivatives.magnified image
Funder
Southwest University
National Natural Science Foundation of China
Natural Science Foundation of Chongqing