Affiliation:
1. School of Chemistry and Chemical Engineering Guangxi University Nanning 530004 People's Republic of China
2. Guangxi Key Laboratory of Electrochemical Energy Materials Guangxi University Nanning Guangxi 530004 People's Republic of China
3. Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development Guangxi University Nanning Guangxi 530004 People's Republic of China
Abstract
AbstractThe position‐selective functionalization of the poorly reactive benzenoid nucleus of indoles has remained a great challenge in organic chemistry. Here we describe a directing‐group‐free, three‐component tandem C3‐acylation/C5,6‐H disulfenylation of indoles via an iodine‐, Lewis acid‐ and Brønsted acid‐cooperated mediated strategy. This protocol is remarkable for its exceptional regio‐ and chemo‐selectivity, broad substrate scope, good functional group tolerance and mild reaction conditions. Advantageously, the present protocol offers great potential for the development of general site‐selective functionalization at the benzenoid nucleus of indoles, removing the requirement for neighbouring activating groups.magnified image
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangxi Province
Cited by
5 articles.
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