Affiliation:
1. School of Chemistry & Material Science Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University Xuzhou 211116 People's Republic of China
2. Analyzing and Test Center Jiangsu Normal University Xuzhou 211116 People's Republic of China
Abstract
AbstractA Brønsted acid‐catalyzed dearomative skeletal rearrangement of azofurans with indoles is reported, enabling a regioselective 1,6‐addition, ring‐opening and 1,4‐addition cascade to produce 26 examples of indolylated pyrrol‐2‐ones with a cyclic tetrasubstituted stereocenter in 58–94% yields. This protocol demonstrates remarkable compatibility regarding azofurans and indoles with different substitution patterns, featuring complete regioselectivity.
Funder
National Natural Science Foundation of China