Affiliation:
1. Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung 807 Taiwan
2. Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan
3. NPUST College of Professional Studies National Pingtung University of Science and Technology Pingtung 912 Taiwan
Abstract
AbstractA one‐pot synthesis method for functionalized bis‐sulfonyl dibenzofurans was developed under an air atmosphere using potassium carbonate‐mediated benzannulation of diversified α‐sulfonyl o‐hydroxyacetophenones with 1,4‐dichloro‐2‐butyne. A plausible mechanism was proposed and discussed. This method provides intermolecular double α‐propargylation, sulfonyl migration, and intramolecular ring‐closure via the formation of one carbon‐oxygen single (C−O) bond, one carbon‐sulfur single (C−S) bond, and two carbon‐carbon (C=C) double bonds.