Psychological Status as an Effect Modifier of the Association Between Allergy Symptoms and Allergy Testing

Author:

Kim Minjee12,Li Anne3,Prince Anthony A.1,Nadkarni Ashwini4,Louisias Margee5,Corrales Carleton Eduardo1,Gilani Sapideh3,Shin Jennifer J.1236

Affiliation:

1. Department of Otolaryngology–Head and Neck Surgery Harvard Medical School Boston Massachusetts USA

2. Center for Surgery and Public Health Brigham and Women's Hospital Boston Massachusetts USA

3. Department of Surgery Brigham and Women's Hospital Boston Massachusetts USA

4. Department of Psychiatry Brigham and Women's Hospital Boston Massachusetts USA

5. Division of Allergy and Clinical Immunology, Department of Medicine Brigham and Women's Hospital Boston Massachusetts USA

6. Harvard Medical School Harvard University Boston Massachusetts USA

Abstract

AbstractObjectivePatient‐reported outcome measures, while valuable, may not correlate with diagnostic test results. To better understand this potential discrepancy, our objective was to determine whether psychological health is an effect modifier of the association between patient‐reported allergy outcome scores and allergy test results.Study DesignProspective outcomes study.SettingTertiary care hospital and community‐based clinic.MethodsThis study included 600 patients at least 18 years of age who presented for symptoms related to allergic rhinitis and completed the related sinonasal outcome test (SNOT), which includes validated nasal, allergy, and psychological domains. Stratified analyses of odds ratios and Spearman correlation coefficients were utilized to assess for effect modification by psychological status.ResultsWorse patient‐reported allergic rhinitis symptoms were significantly associated with positive allergy test results (odds ratio [OR] 1.69, 95% confidence interval [CI] 1.22‐2.34, P = .002) in patients with better psychological health. In contrast, there was no association in patients with worse psychological health (OR 1.06, 95% CI 0.36‐3.10, P = .92). These findings were corroborated by assessments of correlation: allergy domain scores were positively correlated with allergy testing scores (Spearman rho 0.18, 95% CI 0.10‐0.25, P < .001) in patients with better psychological health, while there was no correlation in patients with worse psychological health (−0.02, 95% CI −0.16‐0.12, P = .77).ConclusionsPsychological status was an effect modifier of the association between allergy domain and allergy testing data. When assessing the relationship between subjective measures, such as sinonasal validated instruments, and objective measures, such as allergy test results, accounting for effect modifiers such as psychological state can provide clinical and research‐related insights.

Publisher

Wiley

Reference39 articles.

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