Affiliation:
1. Department of Life Science and Technology, School of Life Science and Technology Tokyo Institute of Technology Yokohama Japan
2. Department of Bioprocess Engineering (BPE) Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg Germany
Abstract
AbstractOne of the most frequently used biocatalysts for organic synthesis is lipase, a triacylglycerol hydrolase, that also catalyzes esterification in non‐aqueous solvents. Various non‐aqueous solvents such as organic solvents, ionic liquids, and pressurized carbon dioxide (CO2) have been employed for lipase‐catalyzed reactions. Notably, pressurized CO2 (supercritical CO2, liquid CO2, CO2‐expanded liquid) serves as a functional green solvent. This review briefly outlines the properties of pressurized CO2 relevant to biocatalysis and provides examples of utilizing pressurized CO2 solvents for efficient synthesis with immobilized lipases.
Funder
Japan Society for the Promotion of Science