Association of Alzheimer's Disease With Peripheral Vestibular Disorder: A Case–Control Study

Author:

Hung Shih‐Han123ORCID,Xirasagar Sudha4,Cheng Yen‐Fu5678ORCID,Lin Herng‐Ching910ORCID,Chen Chin‐Shyan811

Affiliation:

1. Department of Otolaryngology, School of Medicine Taipei Medical University Taipei Taiwan

2. Department of Otolaryngology Wan Fang Hospital Taipei Taiwan

3. International Ph.D. Program in Medicine, College of Medicine Taipei Medical University Taipei Taiwan

4. Department of Health Services Policy and Management, Arnold School of Public Health University of South Carolina Columbia South Carolina USA

5. Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan

6. Department of Otolaryngology‐Head and Neck Surgery Taipei Veterans General Hospital Taipei Taiwan

7. Department of Otolaryngology‐Head and Neck Surgery, School of Medicine National Yang Ming Chiao Tung University Hsinchu Taiwan

8. Research Center of Data Science on Healthcare Industry, College of Management Taipei Medical University Taipei Taiwan

9. School of Health Care Administration, College of Management Taipei Medical University Taipei Taiwan

10. Research Center of Sleep Medicine Taipei Medical University Hospital Taipei Taiwan

11. Department of Economics National Taipei University No. 151, University Rd., Sanxia Dist New Taipei City 237303 Taiwan

Abstract

ObjectivesVestibular disorders can impact cognitive domains, including spatial orientation and memory, which are also affected in Alzheimer's disease. This study aimed to examine the association between Alzheimer's disease and a prior diagnosis of peripheral vestibular disorders in the elderly Taiwanese population.MethodsThe case–control study sample was retrieved from Taiwan's Longitudinal Health Insurance Database 2010. We included 3138 cases with Alzheimer's disease and 9414 propensity‐matched controls. We conducted multivariable logistic regression modeling to investigate the association between Alzheimer's disease and a prior diagnosis of peripheral vestibular disorders after accounting for sociodemographic characteristics and medical comorbidities including diabetes, coronary heart disease, hypertension, hyperlipidemia, and hearing loss.ResultsThe results revealed a statistically significant difference in the prevalence of prior peripheral vestibular disorders between patients with Alzheimer's disease and controls; 20.6% among patients with Alzheimer's disease and 11.4% among controls (p < 0.001). Multivariable logistic regression analysis found that patients with Alzheimer's disease were twice as likely as controls to have had a prior diagnosis of peripheral vestibular disorders, adjusted odds ratio 2.040 (95% confidence interval: 1.829–2.274).ConclusionsThe findings suggest the possibility of shared or related pathophysiological pathways in Alzheimer's disease and vestibular dysfunction disorders.Level of Evidence3 Laryngoscope, 2024

Publisher

Wiley

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5. An overview of auditory and vestibular disorders in Alzheimer's disease: a narrative review;Iran Pour Mobarakeh Z;J Rehabil Sci Res,2022

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