Allopurinol use during pediatric acute lymphoblastic leukemia maintenance therapy safely corrects skewed 6‐mercaptopurine metabolism, improving inadequate myelosuppression and reducing gastrointestinal toxicity

Author:

Cohen Gordon1,Cooper Stacy1ORCID,Sison Edward Allan2,Annesley Colleen3,Bhuiyan Mariam4,Brown Patrick1

Affiliation:

1. Division of Pediatric Oncology, Department of Oncology Johns Hopkins University School of Medicine Baltimore Maryland

2. Section of Hematology‐Oncology, Department of Pediatrics, Baylor College of Medicine Texas Children's Cancer and Hematology Centers Houston Texas

3. Department of Pediatrics Seattle Children's Hospital, University of Washington Seattle Washington

4. Johns Hopkins University School of Medicine Baltimore Maryland

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology, and Child Health

Reference17 articles.

1. Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia;Kjeld S;J Clin Oncol,2003

2. Inotuzumab ozogamicin and frontline chemotherapy in treating young adults with newly diagnosed B acute lymphoblastic leukemia. ClinicalTrials.gov. Accessed 20 Mar2018.

3. Efficacy and safety of imatinib on top of BFM‐like chemotherapy in pediatric patients with ph+/BCR‐ABL+ acute lymphoblastic leukemia (Ph+ALL). The EsPhALL study;Biondi A;Blood,2011

4. Children's Oncology Group AALL0932“Treatment of patients with newly diagnosed standard risk B‐lymphoblastic leukemia (B‐ALL) or Localized B‐lineage lymphoblastic lymphoma” version data 10/26/2017.

5. Treatment of acute lymphoblastic leukemia in adults

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