Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta‐analysis-Reference-Cited by-同舟云学术

Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta‐analysis

Published:2024-06-09 Issue:8 Volume:46 Page:2086-2097
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Tsai Yao‐Te¹²^ORCID,Kuo Liang‐Tseng²³,Wang Yun‐Ting¹²^ORCID,De Vito Andrea⁴,Hao Sheng‐Po⁵,Fang Ku‐Hao²⁶,Lee Yi‐Chan²⁷^ORCID,Chen Kuan‐Yin⁸,Lai Chia‐Hsuan²⁹,Tsai Yuan‐Hsiung²¹⁰,Huang Ethan I.¹²,Tsai Ming‐Shao¹²,Hsu Cheng‐Ming¹²,Chang Geng‐He¹²,Luan Chih‐Wei²¹¹¹²^ORCID

Affiliation:

1. Department of Otorhinolaryngology – Head and Neck Surgery Chang Gung Memorial Hospital Chiayi Taiwan

2. College of Medicine Chang Gung University Taoyuan Taiwan

3. Division of Sports Medicine, Department of Orthopedic Surgery Chang Gung Memorial Hospital Chiayi Taiwan

4. Ear Nose Throat (ENT) Unit, Department of Surgery Forlì Hospital Health Local Agency of Romagna Forlì Italy

5. Department of Otolaryngology – Head and Neck Surgery Shin Kong Wu Ho‐Su Memorial Hospital Taipei Taiwan

6. Department of Otorhinolaryngology – Head and Neck Surgery Chang Gung Memorial Hospital Taoyuan Taiwan

7. Department of Otorhinolaryngology – Head and Neck Surgery Chang Gung Memorial Hospital Keelung Taiwan

8. School of Dentistry National Yang Ming University Taipei Taiwan

9. Department of Radiation Oncology Chang Gung Memorial Hospital Chiayi Taiwan

10. Department of Diagnostic Radiology Chang Gung Memorial Hospital Chiayi Taiwan

11. Lunghwa University of Science and Technology Taoyuan Taiwan

12. Department of Otorhinolaryngology – Head and Neck Surgery LO‐Sheng Hospital Ministry of Health and Welfare‐Home New Taipei City Taiwan

Abstract

AbstractWe conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random‐effects meta‐analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression‐free survival (HR = 1.87, 95% CI = 1.32–2.65, p < 0.001) and overall survival (HR = 3.04, 95% CI = 2.30–4.03, p < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.

Funder

Chang Gung Medical Foundation

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27842

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