Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice

Author:

Salzer Ralf1ORCID,Clark Jordan J.2ORCID,Vaysburd Marina1ORCID,Chang Veronica T.1ORCID,Albecka Anna1ORCID,Kiss Leo1ORCID,Sharma Parul2ORCID,Gonzalez Llamazares Andres1ORCID,Kipar Anja23ORCID,Hiscox Julian A.2ORCID,Owen Andrew4ORCID,Aricescu A. Radu1ORCID,Stewart James P.2ORCID,James Leo C.1ORCID,Löwe Jan1ORCID

Affiliation:

1. MRC Laboratory of Molecular Biology Cambridge UK

2. Institute of Infection, Veterinary and Ecological Sciences University of Liverpool UK

3. Laboratory for Animal Model Pathology Institute of Veterinary Pathology Vetsuisse Faculty University of Zurich Switzerland

4. Department of Pharmacology and Therapeutics Centre of Excellence in Long‐acting Therapeutics (CELT) University of Liverpool UK

Funder

Medical Research Council

Food and Drug Administration

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Reference62 articles.

1. WHO declares COVID‐19 a pandemic;Cucinotta D;Acta Biomed,2020

2. The New York Times Coronavirus Vaccine Tracker(The New York Times) (2021).

3. World Health Organization COVID‐19 situation reports(2021).

4. Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2): an update;Pal M;Cureus,2020

5. Biochemical characterization of SARS-CoV-2 nucleocapsid protein

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