Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling-Reference-Cited by-同舟云学术

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Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling

Published:2016-06 Issue:6 Volume:5 Page:313-323
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Almquist J¹²³,Penney M⁴,Pehrsson S³,Sandinge A‐S³,Janefeldt A³,Maqbool S⁴,Madalli S⁵,Goodman J⁴,Nylander S³,Gennemark P³

Affiliation:

1. Fraunhofer‐Chalmers Centre, Chalmers Science ParkGothenburg Sweden

2. Systems and Synthetic Biology, Department of Biology and Biological EngineeringChalmers University of TechnologyGothenburg Sweden

3. Cardiovascular and Metabolic Diseases, Innovative Medicines, AstraZeneca R&DMölndal Sweden

4. Clinical Pharmacology and DMPK, MedImmuneCambridge UK

5. Cardiovascular and Metabolic Diseases Research, MedImmuneCambridge UK

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12089

Reference27 articles.

1. Ticagrelor binds to human P2Y12independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation

2. Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

3. Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation

4. Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes

5. Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction

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2. Clinical and Pre-Clinical Pharmacokinetics and Pharmacodynamics of Bentracimab;Clinical Pharmacokinetics;2023-04-28

3. Population pharmacokinetic–pharmacodynamic modeling of PB2452, a monoclonal antibody fragment being developed as a ticagrelor reversal agent, in healthy volunteers;CPT: Pharmacometrics & Systems Pharmacology;2021-11-09

4. Translational PK/PD and model‐informed development of JNJ‐67842125, a F ab reversal agent for JNJ‐64179375, a long‐acting thrombin inhibitor;British Journal of Pharmacology;2021-06-29

5. Pharmacokinetic Modeling of Morphine’s Effect on Plasma Concentrations of Ticagrelor and Its Metabolite in Healthy Volunteers;Frontiers in Physiology;2021-06-24

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