Affiliation:
1. Univ. Grenoble Alpes, INSERM 1209, CNRS 5309 Institute for Advanced Biosciences Grenoble France
2. Cell death and Childhood Cancers team, Cancer Research Center of Lyon, INSERM U1052, CNRS UMR5286 University of Lyon, Centre Léon Bérard Lyon France
Abstract
AbstractNeural crest cells (NCCs) are highly motile, multipotent, embryonic cells that delaminate from the dorsal edges of the neural tube. NCCs follow stereotypical long‐range migratory pathways to reach target organs during development, where they give rise to multiple derivatives. The identification of reservoirs of neural crest stem cells that persist to adulthood has recently aroused renewed interest in the biology of NCCs. In this context, several recent studies have demonstrated the essential role of the metabolic kinase LKB1 in NCC establishment. This review surveys how LKB1 governs the formation and maintenance of several neural crest derivatives, including facial bones, melanocytes, Schwann cells, and the enteric nervous system. We also detail the underlying molecular mechanisms that involve downstream effectors of LKB1, in particular the contribution of the AMPK‐mTOR signaling pathway to both polarity and metabolic processes. Collectively, these recent discoveries open promising perspectives for new therapeutic applications for the treatment of neural crest disorders.
Funder
Association pour la Recherche sur le Cancer
Cited by
1 articles.
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