Amorphous solid dispersions of carvedilol along with pH-modifiers improved pharmacokinetic properties under hypochlorhydoria

Author:

Halder Shimul1,Tabata Aiko1,Seto Yoshiki1ORCID,Sato Hideyuki1ORCID,Onoue Satomi1

Affiliation:

1. Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences; University of Shizuoka; 52-1 Yada Suruga-ku Shizuoka 422-8526 Japan

Funder

Takeda Science Foundation

Japan Society for the Promotion of Science

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference43 articles.

1. Inhibition of ethanol-induced gastric mucosal damage by carvedilol in male Wistar albino rats : Possible biochemical changes;Al-Rajaie;International Journal of Pharmacology,2009

2. Enhancing and Sustaining AMG 009 Dissolution from a Bilayer Oral Solid Dosage Form via Microenvironmental pH Modulation and Supersaturation;Bi;AAPS PharmSciTech,2011

3. Carvedilol: a nonselective beta blocking agent with antioxidant properties;Book;Congestive Heart Failure (Greenwich, Conn.),2002

4. Brook , C. S. Chen , P. Y. Chen , W. Dai , Q. Dell'Orco , P. C. Labaw , C. S. C. Werner 2010 Carvedilol salts, corresponding compositions, methods of delivery and/or treatment

5. Modifying matrix micro-environmental pH to achieve sustained drug release from highly laminating alginate matrices;Ching;European Journal of Pharmaceutical Sciences,2008

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