Affiliation:
1. Department of Endocrinology Zhongda Hospital Institute of Diabetes School of Medicine Southeast University Nanjing China
2. Department of Endocrinology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei China
3. Department of Obstetrics and Gynecology The First Affiliated Hospital of USTC University of Science and Technology of China Hefei China
4. Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China
Abstract
AbstractAimsTo explore the relationship between preconception severe hypoglycemia (PSH) and pregnancy outcomes in pregnancies complicated with type 1 diabetes mellitus (T1DM).Materials and MethodsIn this multicenter prospective cohort study, women with pregestational T1DM were stratified by episodes of severe hypoglycemia within 1 year before conception: No PSH, sporadic PSH (1–6 times/year), and recurrent PSH (>6 times/year). We analysed the predictive ability of PSH for maternal and neonatal outcomes using log‐binomial regression models and receiver operating characteristic (ROC) curve.ResultsOf the 124 women studied, 37.1% experienced at least one episode of severe hypoglycemia preconception. In the multiple adjusted regression models, recurrent PSH was significantly associated with increased incidence of preeclampsia (RR 17.59, 95% CI: 2.89–150.62, p for trend = 0.007), preterm birth (RR 6.34, 95% CI: 1.22–40.63, p for trend = 0.027), neonatal hypoglycemia (RR 4.52, 95% CI: 1.14–17.16, p for trend = 0.017), neonatal hyperbilirubinemia (RR 4.12, 95% CI: 1.11–15.56, p for trend = 0.004), and composite neonatal outcome (RR 3.85, 95% CI: 1.01–19.61, p for trend = 0.003). In the ROC analysis, PSH predicted preeclampsia, preterm birth, neonatal hypoglycemia, neonatal hyperbilirubinemia, and composite neonatal outcome with areas under the ROC curve all ≥0.6.ConclusionsRecurrent preconception severe hypoglycemia is associated with increased risks of adverse outcomes in pregnant women with T1DM.
Funder
National Natural Science Foundation of China
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine