Comparing opium tincture and methadone for medication-assisted treatment of patients with opioid use disorder: Protocol for a multicenter parallel group noninferiority double-blind randomized controlled trial

Author:

Nikoo Mohammadali1,Moazen-Zadeh Ehsan12ORCID,Nikoo Nooshin3,Javidanbardan Sanam3ORCID,Kazemi Alireza34,Choi Fiona1,Vogel Marc5,Gholami Ali6,Tavakoli Saeed7,Givaki Reza8,Jazani Majid9,Mohammadian Fatemeh10,Markazi Moghaddam Nader11,Goudarzi Nasser12,Schutz Christian13,Jang Kerry13,Akhondzadeh Shahin2,Krausz Michael1

Affiliation:

1. Addiction and Concurrent Disorders Group, Institute of Mental Health, Centre for Health Evaluation and Outcome Sciences, Department of Psychiatry; University of British Columbia; Vancouver Canada

2. Psychiatric Research Center, Roozbeh Hospital, Department of Psychiatry; Tehran University of Medical Sciences; Tehran Iran

3. Addiction and Concurrent Disorders Group, Institute of Mental Health, Department of Psychiatry; University of British Columbia; Vancouver Canada

4. Health Information Management and Technology Group; Shahid Beheshti University of Medical Sciences; Tehran Iran

5. Department of Psychiatry (UPK), Division of Addictive Disorders; University of Basel; Basel Switzerland

6. Kian Methadone Maintenance Treatment Clinic, Private Practice and Mazandaran University of Medical Sciences; Sari Mazandaran Iran

7. Rooz-e-No Methadone Maintenance Treatment Clinic, Private Practice and Shiraz University of Medical Sciences; Shiraz Fars Iran

8. Psychosomatic Research Center; Isfahan University of Medical Sciences; Isfahan Iran

9. Sales, Marketing, Export, and Medical Department; Darou Pakhsh Pharmaceutical Mfg.Co.; Tehran Iran

10. Pharmacovigilance & Clinical Trial Manager, Darou Pakhsh Pharmaceutical Mfg Co.; Tehran Iran

11. Department of Health Management and Economics, School of Medicine; AJA University of Medical Sciences; Tehran Iran

12. Department of Psychology; AJA University of Medical Sciences; Tehran Iran

13. Institute of Mental Health, Department of Psychiatry, Faculty of Medicine; University of British Columbia; Vancouver Canada

Funder

The Iran National Science Foundation

Tehran University of Medical Sciences and Health Services

AJA University of Medical Sciences

Publisher

Wiley

Subject

Psychiatry and Mental health

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