Modeling and Simulation of N‐(3‐Aminio‐4 methylphenyl)benzamide Synthesis in a Microreactor

Abstract

AbstractN‐(3‐Amino‐4‐methylphenyl)benzamide is an intermediate product for the production of several medicines. Microreactor technology is a new concept for the continuous synthesis of chemicals. The computational fluid dynamics method was used to simulate the flow synthesis of N‐(3‐amino‐4‐methylphenyl)benzamide. There was good agreement between experimental data and modeling outputs. The effect of operating parameters such as temperature and residence time on system performance was investigated. The results revealed that an increase in temperature from 30 to 70 °C led to the enhancement of N‐(3‐amino‐4‐methylphenyl)benzamide production from about 42 to 76 % at a residence time of 420 s. It was found that the residence time and temperature have the largest influence on N‐(3‐amino‐4‐methylphenyl)benzamide production. Byproduct production was also increased by increasing the temperature and residence time.