Nonlinear plasma surface modification of polylactide to promote interaction with fibroblasts

Abstract

AbstractSurface modification of polylactide films was performed using a dielectric barrier discharge (DBD) with the aim of increasing proliferative activity of human fibroblasts on these films. It has been shown that during the plasma treatment of the polylactide film, nonlinear processes occur depending on the processing time. The effect of the dielectric barrier discharge on the modification of polylactide films was evaluated using IR spectroscopy, AFM, XPS, TSDC, and the wetting angle of the surface. The optimal processing time in DBD of polylactide films is 3 min for this installation, the proliferative activity increases by 10% compared to the original film. This treatment time provides an increased concentration of oxygen‐containing groups, optimal relief, and free surface energy of 55 mJ/m2 on the surface.Highlights The biocompatibility of the polylactide film was improved by 10% used DBD. The optimal processing time of PLA films in DBD is 3 min. The functionalization of the polylactide surface occurs non‐linearly.