Affiliation:
1. Department of Epidemiology and Health Statistics, School of Public Health Hangzhou Medical College Hangzhou China
2. School of Public Health and the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China
3. Vanderbit Genetics Institute Vanderbilt University Medical Center Nashville TN USA
4. School of Public Health Hangzhou Medical College Hangzhou China
5. Zhejiang Provincial Center for Disease Control and Prevention Hangzhou China
Abstract
AbstractBackgroundObservational studies have demonstrated a strong bidirectional association between frailty and depression, but it remains unclear whether this association reflects causality. This study aimed to examine the bidirectional causal relationship between frailty and depression.MethodsUsing genome‐wide association study summary data, two‐sample Mendelian randomization was performed to test for the potential bidirectional causality between frailty, as defined by both the frailty index and the frailty phenotype, and depression. Several frailty‐related traits were additionally investigated, including weaker hand grip strength, slower walking pace and physical inactivity. Findings were replicated using an independent depression data source and verified using multiple sensitivity analyses.ResultsGenetically predicted higher frailty index (odds ratio [OR], 1.86; P < 0.001), higher frailty phenotype score (OR, 2.79; P < 0.001), lower grip strength (OR, 1.23; P = 0.003), slower walking pace (OR, 1.55; P = 0.027) and physical inactivity (OR, 1.44; P = 0.003) all were associated with a higher risk of depression. As for the reverse direction, genetic liability to depression showed consistent associations with a higher frailty index (beta, 0.167; P < 0.001) and a higher frailty phenotype score (beta, 0.067; P = 0.001), but not with other frailty‐related traits that were investigated. The results were stable across sensitivity analyses and across depression datasets.ConclusionsOur findings add novel evidence supporting the bidirectional causal association between frailty and depression. Improving balance and muscle strength and increasing physical activity may be beneficial in both depression and frailty.
Subject
Physiology (medical),Orthopedics and Sports Medicine
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献