Pharmacological potentials of lycopene against aging and aging‐related disorders: A review

Author:

Abir Mehedy Hasan12,Mahamud A. G. M. Sofi Uddin13ORCID,Tonny Sadia Haque4,Anu Mithila Saha5,Hossain K. H. Sabbir4,Protic Ismam Ahmed6,Khan Md Shihab Uddine17,Baroi Artho17,Moni Akhi1,Uddin Md Jamal1ORCID

Affiliation:

1. ABEx Bio‐Research Center Dhaka Bangladesh

2. Faculty of Food Science and Technology Chattogram Veterinary and Animal Sciences University Chattogram Bangladesh

3. Department of Food Safety and Regulatory Science Chung‐Ang University Anseong‐si Gyeonggi‐do Republic of Korea

4. Faculty of Agriculture Bangladesh Agricultural University Mymensingh Bangladesh

5. Department of Fisheries Biology and Genetics Faculty of Fisheries, Bangladesh Agricultural University Mymensingh Bangladesh

6. Department of Plant Pathology Faculty of Agriculture, Bangladesh Agricultural University Mymensingh Bangladesh

7. Department of Crop Botany Faculty of Agriculture, Bangladesh Agricultural University Mymensingh Bangladesh

Abstract

AbstractAging and aging‐related chronic disorders are one of the principal causes of death worldwide. The prevalence of these disorders is increasing gradually and globally. Considering this unwavering acceleration of the global burden, seeking alternatives to traditional medication to prevent the risk of aging disorders is needed. Among them, lycopene, a carotenoid, is abundant in many fruits and vegetables, including tomatoes, grapefruits, and watermelons, and it has a unique chemical structure to be a potent antioxidant compound. This nutraceutical also possesses several anti‐aging actions, including combating aging biomarkers and ameliorating several chronic disorders. However, no systematic evaluation has yet been carried out that can comprehensively elucidate the effectiveness of lycopene in halting the course of aging and the emergence of chronic diseases linked to aging. This review, therefore, incorporates previous pre‐clinical, clinical, and epidemiological studies on lycopene to understand its potency in treating aging disorders and its role as a mimic of caloric restriction. Lycopene‐rich foods are found to prevent or attenuate aging disorders in various research. Based on the evidence, this review suggests the clinical application of lycopene to improve human health and alleviate the prevalence of aging and aging disorders.

Publisher

Wiley

Subject

Food Science

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