Sulfide Analogues of Flupirtine and Retigabine with Nanomolar K V 7.2/K V 7.3 Channel Opening Activity

Author:

Bock Christian1,Surur Abdrrahman S.1,Beirow Kristin1,Kindermann Markus K.1,Schulig Lukas1,Bodtke Anja1,Bednarski Patrick J.1,Link Andreas1ORCID

Affiliation:

1. Institute of PharmacyUniversity of Greifswald Friedrich-Ludwig-Jahn-Str. 17 17489 Greifswald Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference57 articles.

1. Arzneiverordnungs-Report 2018

2.  

3. “Assessment report for flupirtine containing medicinal products” European Medicines Agency document EMA/404308/2013 June 24 2013:http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Flupirtine-containing_medicines/Recommendation_provided_by_Pharmacovigilance_Risk_Assessment_Committee/WC500146103.pdf(accessed March 19 2019);

4. “Withdrawal of pain medicine flupirtine endorsed” European Medicines Agency document EMA/153044/2018 March 23 2018:http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2018/03/WC500246353.pdf(accessed March 19 2019).

5. δ Subunit-containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine

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