1. Center for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences; Nagasaki University; 1-12-4 Sakamoto Nagasaki 852-8523 Japan
2. Second Department of Internal Medicine; Nagasaki University Hospital, Nagasaki University; 1-7-1 Sakamoto Nagsaki 852-8501 Japan
3. Department of Social Work, Faculty of Human and Social Studies; Nagasaki International University; 2825-7 Huis Ten Bosch Sasebo Nagasaki 859-3298 Japan
4. Department of Internal Medicine and the Interdisciplinary Graduate Program in Immunology; University of Iowa Carver College of Medicine, Veterans Affairs Health Care System; 601 Highway 6 West, Research, 151 Iowa City IA 52246 USA