LASSBio-1829 Hydrochloride: Development of a New Orally ActiveN-Acylhydrazone IKK2 Inhibitor with Anti-inflammatory Properties-Reference-Cited by-同舟云学术

LASSBio-1829 Hydrochloride: Development of a New Orally ActiveN-Acylhydrazone IKK2 Inhibitor with Anti-inflammatory Properties

Published:2015-08-25 Issue:2 Volume:11 Page:234-244
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Guedes Isabella A.¹,Freitas Rosana H. C. N.²,Cordeiro Natália M.³,Nascimento Thaís S. do³,Valerio Tayna S.³,Fernandes Patrícia D.³,Dardenne Laurent E.¹,Fraga Carlos A. M.²

Affiliation:

1. Laboratório Nacional de Computação Científica (LNCC/MCTI); Petrópolis RJ Brazil

2. Laboratório de Avaliação e Substâncias Bioativas (LASSBio); Instituto de Ciências Biomédicas (ICB); Universidade Federal do Rio de Janeiro (UFRJ); 21941-902 Rio de Janeiro RJ Brazil

3. Laboratório de Farmacologia da Dor e da Inflamação; ICB; UFRJ; Rio de Janeiro RJ Brazil

Funder

Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos (INCT-INOFAR)

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Coordenadoria de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201500266/fullpdf

Reference76 articles.

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3. The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

4. A HIGHLY SELECTIVE INHIBITOR OF IκB KINASE, BMS-345541, AUGMENTS GRAFT SURVIVAL MEDIATED BY SUBOPTIMAL IMMUNOSUPPRESSION IN A MURINE MODEL OF CARDIAC GRAFT REJECTION

5. IκB kinase β (IKKβ/IKK2/IKBKB)—A key molecule in signaling to the transcription factor NF-κB

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