A Molecular Dynamics-Shared Pharmacophore Approach to Boost Early-Enrichment Virtual Screening: A Case Study on Peroxisome Proliferator-Activated Receptor α-Reference-Cited by-同舟云学术

A Molecular Dynamics-Shared Pharmacophore Approach to Boost Early-Enrichment Virtual Screening: A Case Study on Peroxisome Proliferator-Activated Receptor α

Published:2017-02-17 Issue:16 Volume:12 Page:1399-1407
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Perricone Ugo¹²³^ORCID,Wieder Marcus²⁴,Seidel Thomas²,Langer Thierry²,Padova Alessandro³,Almerico Anna Maria¹,Tutone Marco¹

Affiliation:

1. Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF); Università di Palermo; Via Archirafi 32 90123 Palermo Italy

2. Department of Pharmaceutical Chemistry; Faculty of Life Sciences; University of Vienna; Althanstraße 14 1090 Vienna Austria

3. Fondazione Ri.MED; Via Bandiera 11 90133 Palermo Italy

4. Department of Computational Biological Chemistry; Faculty of Chemistry; University of Vienna; Währinger Straße 42 1090 Vienna Austria

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference67 articles.

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2. International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors

3. Peroxisome Proliferator-Activated Receptor Alpha Target Genes

4. PPAR-α as a Key Nutritional and Environmental Sensor for Metabolic Adaptation

5. The role of PPARα in lipid metabolism and obesity: Focusing on the effects of estrogen on PPARα actions

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