Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma-Reference-Cited by-同舟云学术

Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma

Published:2017-10-30 Issue:22 Volume:12 Page:1893-1905
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Franchini Silvia¹,Sorbi Claudia¹,Battisti Umberto Maria¹,Tait Annalisa¹,Bencheva Leda Ivanova¹,Cichero Elena²,Fossa Paola²,Cilia Antonio³,Prezzavento Orazio⁴,Ronsisvalle Simone⁴,Aricò Giuseppina⁴,Benassi Luisa⁵,Vaschieri Cristina⁵,Azzoni Paola⁵,Magnoni Cristina⁵,Brasili Livio¹^ORCID

Affiliation:

1. Dipartimento di Scienze della Vita; Università degli Studi di Modena e Reggio Emilia; Via Campi 103 41125 Modena Italy

2. Dipartimento di Farmacia; Università degli Studi di Genova; Viale Benedetto XV 3 16132 Genova Italy

3. Divisione Ricerca e Sviluppo; Recordati S.p.A.; Via Civitali 1 20148 Milano Italy

4. Dipartimento di Scienze del Farmaco; Università degli Studi di Catania; Viale Andrea Doria 6 95125 Catania Italy

5. Dipartimento Chirurgico, Medico, Odontoiatrico e di Scienze Morfologiche con interesse Trapiantologico, Oncologico e di Medicina Rigenerativa; Università degli Studi di Modena e Reggio Emilia; via del Pozzo 71 41124 Modena Italy

Funder

The authors would like to thank Fondazione Cassa di Risparmio di Modena for financial support

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference67 articles.

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3. A proposal for the classification of sigma binding sites

4. Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

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