Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ-Reference-Cited by-同舟云学术

Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ

Published:2015-11-10 Issue:2 Volume:11 Page:207-216
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Olsson Roine I.¹,Xue Yafeng²,von Berg Stefan¹,Aagaard Anna²,McPheat Jane²,Hansson Eva L.²,Bernström Jenny²,Hansson Pia²,Jirholt Johan³,Grindebacke Hanna³,Leffler Agnes³,Chen Rongfeng⁴,Xiong Yao⁴,Ge Hongbin⁴,Hansson Thomas G.¹,Narjes Frank¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry; AstraZeneca, Respiratory, Inflammation and Autoimmunity iMed; Pepparedsleden 1 43183 Mölndal Sweden

2. Discovery Sciences; AstraZeneca; Pepparedsleden 1 43183 Mölndal Sweden

3. Department of Bioscience; AstraZeneca, Respiratory, Inflammation and Autoimmunity iMed; Pepparedsleden 1 43183 Mölndal Sweden

4. Department of Medicinal Chemistry; Pharmaron Beijing Co.; 6 Taihe Road, BDA Beijing 10076 P. R. China

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201500432/fullpdf

Reference46 articles.

1. Targeting IL-17 and TH17 cells in chronic inflammation

2. The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

3. A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

4. Deciphering the role of Th17 cells in human disease

5. Recent advances in understanding the molecular mechanisms of the development and function ofTh17 cells

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