Affiliation:
1. Department of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou P.R. China
2. Academy of Medical Sciences of Zhengzhou University Zhengzhou P.R. China
3. Key Clinical Laboratory of Henan Province, Department of Clinical Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou P.R. China
Abstract
AbstractThe central nervous system has long been thought to lack a clearance system similar to the peripheral lymphatic system. Therefore, the clearance of metabolic waste in the central nervous system has been a subject of great interest in neuroscience. Recently, the cerebral lymphatic drainage system, including the parenchymal clearance system and the meningeal lymphatic network, has attracted considerable attention. It has been extensively studied in various neurological disorders. Solute accumulation and neuroinflammation after epilepsy impair the blood–brain barrier, affecting the exchange and clearance between cerebrospinal fluid and interstitial fluid. Restoring their normal function may improve the prognosis of epilepsy. However, few studies have focused on providing a comprehensive overview of the brain clearance system and its significance in epilepsy. Therefore, this review addressed the structural composition, functions, and methods used to assess the cerebral lymphatic system, as well as the neglected association with epilepsy, and provided a theoretical basis for therapeutic approaches in epilepsy.
Funder
National Natural Science Foundation of China
Subject
Cellular and Molecular Neuroscience