Variants in the CYP2B6 3′UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs

Author:

Burgess Kimberly S.12,Ipe Joseph2,Swart Marelize2,Metzger Ingrid F.2,Lu Jessica2,Gufford Brandon T.2,Thong Nancy2,Desta Zeruesenay2,Gaedigk Roger3,Pearce Robin E.3,Gaedigk Andrea3,Liu Yunlong45,Skaar Todd C.2

Affiliation:

1. Department of Pharmacology & Toxicology; Indiana University School of Medicine; Indianapolis Indiana USA

2. Department of Medicine, Division of Clinical Pharmacology; Indiana University School of Medicine; Indianapolis Indiana USA

3. Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City; Kansas City Missouri USA

4. Department of Medical & Molecular Genetics; Indiana University School of Medicine; Indianapolis Indiana USA

5. Center for Computational Biology and Bioinformatics; Indiana University School of Medicine; Indianapolis Indiana USA

Funder

NIH/NIGMS

Clinical Pharmacology Training

Vera Bradley Foundation for Breast Cancer

The National Institute of Child Health and Human Development Brain and Tissue Bank for Developmental Disorders at the University of Maryland

National Institutes of Health

Liver Tissue Cell Distribution System

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

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