Affiliation:
1. Ottawa‐Shanghai Joint School of Medicine, School of Medicine Shanghai Jiao Tong University Shanghai China
2. Philips Healthcare Xi'an Shaanxi China
3. Philips Healthcare Beijing China
4. Department of Radiology, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China
Abstract
BackgroundNative T1 and radiomics were used for hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) differentiation previously. The current problem is that global native T1 remains modest discrimination performance and radiomics requires feature extraction beforehand. Deep learning (DL) is a promising technique in differential diagnosis. However, its feasibility for discriminating HCM and HHD has not been investigated.PurposeTo examine the feasibility of DL in differentiating HCM and HHD based on T1 images and compare its diagnostic performance with other methods.Study TypeRetrospective.Population128 HCM patients (men, 75; age, 50 years ± 16) and 59 HHD patients (men, 40; age, 45 years ± 17).Field Strength/Sequence3.0T; Balanced steady‐state free precession, phase‐sensitive inversion recovery (PSIR) and multislice native T1 mapping.AssessmentCompare HCM and HHD patients baseline data. Myocardial T1 values were extracted from native T1 images. Radiomics was implemented through feature extraction and Extra Trees Classifier. The DL network is ResNet32. Different input including myocardial ring (DL‐myo), myocardial ring bounding box (DL‐box) and the surrounding tissue without myocardial ring (DL‐nomyo) were tested. We evaluate diagnostic performance through AUC of ROC curve.Statistical TestsAccuracy, sensitivity, specificity, ROC, and AUC were calculated. Independent t test, Mann–Whitney U‐test and Chi‐square test were adopted for HCM and HHD comparison. P < 0.05 was considered statistically significant.ResultsDL‐myo, DL‐box, and DL‐nomyo models showed an AUC (95% confidential interval) of 0.830 (0.702–0.959), 0.766 (0.617–0.915), 0.795 (0.654–0.936) in the testing set. AUC of native T1 and radiomics were 0.545 (0.352–0.738) and 0.800 (0.655–0.944) in the testing set.Data ConclusionThe DL method based on T1 mapping seems capable of discriminating HCM and HHD. Considering diagnostic performance, the DL network outperformed the native T1 method. Compared with radiomics, DL won an advantage for its high specificity and automated working mode.Level of Evidence4Technical Efficacy Stage2
Funder
School of Medicine, Shanghai Jiao Tong University
Subject
Radiology, Nuclear Medicine and imaging
Cited by
7 articles.
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