A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice
Author:
Affiliation:
1. Merck& Co., Inc.; Kenilworth NJ USA
2. MSD A/S Copenhagen; Denmark
3. University College; London UK
Funder
Merck
Publisher
Wiley
Subject
Endocrinology, Diabetes and Metabolism
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/edm2.2/fullpdf
Reference27 articles.
1. A Comparative Review of DPP-4 Inhibitors and Sulphonylureas;Deacon;Diabetes Obes Metab,2015
2. Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes;Holst;Diabetes,1998
3. Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects;Deacon;Diabetes,1995
4. Dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes treated with saxagliptin, sitagliptin, or vildagliptin;Tatosian;Diabetes Ther,2013
5. A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site;Nabeno;Biochem Biophys Res Commun,2013
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