Affiliation:
1. Department of Medical Biochemistry, Faculty of Medicine Zonguldak Bülent Ecevit University Zonguldak Turkey
2. Department of Medical Biochemistry, Faculty of Medicine Hacettepe University Ankara Turkey
3. Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine Hacettepe University Ankara Turkey
Abstract
AbstractPhotobiomodulation (PBM) has emerged as a potentially effective therapeutic approach to modulate cellular functions. This study aimed to examine the impact of PBM on reactive oxygen species (ROS), lipid peroxidation, and glutathione‐related antioxidant defense systems in rabbit eye tissues. A polychromatic light source with an intensity of 2.6 J/cm2/min was used for PBM treatment in New Zealand White rabbits for 12 min. The PBM group (n = 8) received treatments every 2 days for a total of 12 sessions, whereas the control group (n = 8) did not undergo any PBM light exposure during the same period. The application of PBM significantly elevated ROS‐mediated glutathione levels, along with increased activities of glutathione peroxidase and reductase, particularly in corneal tissue (p ≤ 0.05). In conclusion, PBM treatment effectively enhances antioxidant defense mechanisms in the eye, particularly in corneal tissue, suggesting its potential as a therapeutic strategy for managing oxidative stress‐related ocular conditions.
Funder
Zonguldak Bülent Ecevit Üniversitesi
Hacettepe Üniversitesi