Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions

Author:

Moretti Rocco1,Fleishman Sarel J.2,Agius Rudi3,Torchala Mieczyslaw3,Bates Paul A.3,Kastritis Panagiotis L.4,Rodrigues João P. G. L. M.4,Trellet Mikaël4,Bonvin Alexandre M. J. J.4,Cui Meng5,Rooman Marianne6,Gillis Dimitri6,Dehouck Yves6,Moal Iain7,Romero-Durana Miguel7,Perez-Cano Laura7,Pallara Chiara7,Jimenez Brian7,Fernandez-Recio Juan7,Flores Samuel8,Pacella Michael9,Praneeth Kilambi Krishna10,Gray Jeffrey J.1011,Popov Petr1213,Grudinin Sergei1213,Esquivel-Rodríguez Juan14,Kihara Daisuke1415,Zhao Nan16,Korkin Dmitry16,Zhu Xiaolei17,Demerdash Omar N. A.17,Mitchell Julie C.17,Kanamori Eiji18,Tsuchiya Yuko19,Nakamura Haruki20,Lee Hasup21,Park Hahnbeom21,Seok Chaok21,Sarmiento Jamica22,Liang Shide22,Teraguchi Shusuke22,Standley Daron M.22,Shimoyama Hiromitsu23,Terashi Genki23,Takeda-Shitaka Mayuko23,Iwadate Mitsuo24,Umeyama Hideaki24,Beglov Dmitri25,Hall David R.25,Kozakov Dima25,Vajda Sandor25,Pierce Brian G.26,Hwang Howook26,Vreven Thom26,Weng Zhiping26,Huang Yangyu27,Li Haotian27,Yang Xiufeng27,Ji Xiaofeng27,Liu Shiyong27,Xiao Yi27,Zacharias Martin28,Qin Sanbo29,Zhou Huan-Xiang29,Huang Sheng-You3031,Zou Xiaoqin3031,Velankar Sameer32,Janin Joël33,Wodak Shoshana J.3435,Baker David136

Affiliation:

1. Department of Biochemistry; University of Washington; Seattle Washington 98195

2. Department of Biological Chemistry; Weizmann Institute of Science; Rehovot 76100 Israel

3. Biomolecular Modelling Laboratory; Cancer Research UK London Research Institute; London WC2A 3LY United Kingdom

4. Bijvoet Center for Biomolecular Research; Faculty of Science - Chemistry; Utrecht University; Padualaan 8 3584 CG Utrecht The Netherlands

5. Department of Physiology and Biophysics; Virginia Commonwealth University; Richmond Virginia 23298

6. Department of BioModelling; BioInformatics and BioProcesses; Université Libre de Bruxelles (ULB); 1050 Brussels Belgium

7. Joint BSC-IRB Research Program in Computational Biology; Life Sciences Department; Barcelona Supercomputing Center C/Jordi Girona 29 08034 Barcelona Spain

8. Department of Cell and Molecular Biology; Uppsala University; Uppsala 75124 Sweden

9. Department of Biomedical Engineering; Johns Hopkins University; Baltimore Maryland 21218

10. Department of Chemical and Biomolecular Engineering; Johns Hopkins University; Baltimore Maryland 21218

11. Program in Molecular Biophysics; Johns Hopkins University; Baltimore Maryland 21218

12. NANO-D, INRIA Grenoble-Rhone-Alpes Research Center; 38334 Saint Ismier Cedex Montbonnot France

13. CNRS, Laboratoire Jean Kuntzmann; BP 53, Grenoble Cedex 9 France

14. Department of Computer Science; Purdue Universit; West Lafayette Indiana 47907

15. Department of Biological Sciences; Purdue University; West Lafayette Indiana 47907

16. Informatics Institute and Department of Computer Science; University of Missouri-Columbia; MO 65211

17. Departments of Mathematics and Biochemistry; University of Wisconsin; Madison Wisconsin 53706

18. Japan Biological Informatics Consortium; Tokyo 135-0064 Japan

19. Division of Life Sciences; Graduate School of Humanities and Sciences; Ochanomizu University; Tokyo 122-8610 Japan

20. Institute for Protein Research; Osaka University; Osaka 565-0871 Japan

21. Department of Chemistry; Seoul National University; Seoul 151-747 Korea

22. Systems Immunology Lab; WPI Immunology Frontier Research Center (IFReC), Osaka University; 3-1 Yamadaoka Suita Osaka 565-0871 Japan

23. School of Pharmacy; Kitasato University; 108-8641 Japan

24. Department of Biological Sciences; Faculty of Science and Engineering; Chuo University; Tokyo 192-0393 Japan

25. Department of Biomedical Engineering; Boston University; Boston Massachusetts 02215

26. Program in Bioinformatics and Integrative Biology; University of Massachusetts Medical School; Worcester Massachusetts 01605

27. Huazhong University of Science and Technology; 430074 Wuhan China

28. Physics Department; Technical University Munich; 85748 Garching Germany

29. Department of Physics and Institute of Molecular Biophysics; Florida State University; Tallahassee Florida 32306

30. Department of Physics and Astronomy; Dalton Cardiovascular Research Center, Informatics Institute, University of Missouri-Columbia; Columbia; Missouri 65211

31. Department of Biochemistry; Dalton Cardiovascular Research Center, Informatics Institute, University of Missouri-Columbia; Columbia; Missouri 65211

32. European Bioinformatics Institute, Wellcome Trust Genome Campus; Hinxton Cambridgeshire CB10 1SD United Kingdom

33. IBBMC, Université Paris-Sud; 91405 Orsay France

34. Department of Biochemistry; University of Toronto; Ontario M5S 1A8 Canada

35. Hospital for Sick Children; 555 University Avenue Toronto Ontario M5K 1X8 Canada

36. Howard Hughes Medical Institute, University of Washington; Seattle Washington 98195

Funder

National Science Foundation

Spanish Ministry of Science

Defense Threat Reduction Agency

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

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