Engineering Photosynthetic Microbial Consortia for Carbon‐Negative Biosynthesis

Abstract

AbstractMicrobial consortia consisting of phototrophs and heterotrophs have raised extensive attention due to their potential in sustainable biotechnology. The challenge remains in the selection of appropriate partners since most heterotrophic microorganisms cannot naturally use the intermediate carbohydrates secreted by autotrophic partners. In a recent study, the Ni Lab has developed a highly compatible autotrophic‐heterotrophic symbiotic system comprisingSynechococcus elongatusandVibrio natriegens. V. natriegens(the sucrose utilization module) shows a high degree of nutritional complementarity and culturing compatibility with the engineeredS. elongatus(the CO2sequestration module). The combination of both species channels CO2into various valuable chemicals, enabling carbon‐negative biosynthesis.