Affiliation:
1. State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering Lanzhou University 222 South Tianshui Road Lanzhou, Gansu Province 730000 China
Abstract
AbstractWe have accomplished the first and asymmetric total synthesis of principinol B, a grayanoid possessing an oxabicyclo[3.2.1] architecture. A functionalized 5/7/6/5 tetracyclic intermediate was assembled in a convergent manner by a diastereoselective intermolecular aldol reaction and subsequent carbonyl–olefin metathesis of two enantiomerically enriched fragments. The oxabicyclo[3.2.1] architecture containing a 6,10‐ether bridge was constructed by the Williamson ether synthesis.
Funder
National Natural Science Foundation of China
Science and Technology Department of Gansu Province
Fundamental Research Funds for the Central Universities