Relating Conformational Equilibria to Conformer‐Specific Lipophilicities: New Opportunities in Drug Discovery-Reference-Cited by-同舟云学术

Relating Conformational Equilibria to Conformer‐Specific Lipophilicities: New Opportunities in Drug Discovery

Published:2021-12-29 Issue:7 Volume:134 Page:
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angewandte Chemie

Author:

Linclau Bruno¹²^ORCID,Wang Zhong¹^ORCID,Jeffries Benjamin¹,Graton Jérôme³,Carbajo Rodrigo J.⁴,Sinnaeve Davy⁵⁶,Le Questel Jean‐Yves³,Scott James S.⁴,Chiarparin Elisabetta⁴

Affiliation:

1. School of Chemistry University of Southampton Highfield, Southampton SO17 1BJ UK

2. Department of Organic and Macromolecular Chemistry, Ghent University Campus Sterre, S4 Krijgslaan 281 9000 Ghent Belgium

3. CEISAM UMR CNRS 6230 Université de Nantes CNRS CEISAM UMR 6230 44000 Nantes France

4. Medicinal Chemistry, Oncology R&D AstraZeneca Cambridge CB4 0WG UK

5. Univ. Lille Inserm Institut Pasteur de Lille CHU Lille U1167—RID-AGE—Risk Factors and Molecular Determinants of Aging-Related Diseases 59000 Lille France

6. CNRS ERL9002—Integrative Structural Biology 59000 Lille France

Funder

Fonds Wetenschappelijk Onderzoek

Engineering and Physical Sciences Research Council

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.202114862

Reference55 articles.

1. Dose Predictions for Drug Design

2. Lipophilicity in drug discovery

4. Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety

5. Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations

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