Biosynthesis of Cosmosporasides Reveals the Assembly Line for Fungal Hybrid Terpenoid Saccharides

Author:

Yuan Guan‐Yin1,Zhang Jin‐Mei1,Xu Qing‐Dong1,Zhang Hua‐Ran1,Hu Changhua1,Zou Yi1ORCID

Affiliation:

1. College of Pharmaceutical Sciences Southwest University Chongqing 400715 P. R. China

Abstract

AbstractFungal hybrid terpenoid saccharides constitute a new and growing family of natural products with significant biomedical and agricultural activities. One representative family is the cosmosporasides, which feature oxidized terpenoid units and saccharide moieties; however, the assembly line of these building blocks has been elusive. Herein, a cos cluster from Fusarium orthoceras was discovered for the synthesis of cosmosporaside C (1) by genome mining. A UbiA family intramembrane prenyltransferase (UbiA‐type PT), a multifunctional cytochrome P450, an α,β‐hydrolase, an acetyltransferase, a dimethylallyl transferase (DMAT‐type PT) and a glycosyltransferase function cooperatively in the assembly of the scaffold of 1 using primary central metabolites. The absolute configuration at C4, C6 and C7 of 1 was also established. Our work clarifies the unexpected functions of UbiA‐type and DMAT‐type PTs and provides an example for understanding the synthetic logic of hybrid terpenoid saccharides in fungi.

Funder

National Natural Science Foundation of China

Science Fund for Distinguished Young Scholars of Chongqing Municipality

Publisher

Wiley

Subject

General Medicine

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