π–π Interaction‐Induced Organic Long‐wavelength Room‐Temperature Phosphorescence for In Vivo Atherosclerotic Plaque Imaging

Author:

Zhang Yufan1,Li Jisen1,Zhao Jiliang1,Li Xuefei1,Wang Zhimei1,Huang Yicheng2,Zhang Hongkai1,Liu Qian3,Lei Yunxiang2,Ding Dan1ORCID

Affiliation:

1. Frontiers Science Center for Cell Responses State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education College of Life Sciences Nankai University 300071 Tianjin China

2. School of Chemistry and Materials Engineering Wenzhou University 325035 Wenzhou China

3. Department of Urology Tianjin First Central Hospital 300192 Tianjin China

Abstract

AbstractRoom‐temperature phosphorescent (RTP) materials have great potential for in vivo imaging because they can circumvent the autofluorescence of biological tissues. In this study, a class of organic‐doped long‐wavelength (≈600 nm) RTP materials with benzo[c][1,2,5] thiadiazole as a guest was constructed. Both host and guest molecules have simple structures and can be directly purchased commercially at a low cost. Owing to the long phosphorescence wavelength of the doping system, it exhibited good tissue penetration (10 mm). Notably, these RTP nanoparticles were successfully used to image atherosclerotic plaques, with a signal‐to‐background ratio (SBR) of 44.52. This study provides a new approach for constructing inexpensive red organic phosphorescent materials and a new method for imaging cardiovascular diseases using these materials.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Medicine

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