Mesoscale Clusters in the Crystallisation of Organic Molecules

Author:

Barua Harsh1ORCID,Svärd Michael2ORCID,Rasmuson Åke C.12ORCID,Hudson Sarah P.1ORCID,Cookman Jennifer1ORCID

Affiliation:

1. Chemical Sciences Department, SSPC The Science Foundation Ireland Research Centre for Pharmaceuticals Bernal Institute University of Limerick Castletroy Limerick V94 T9PX Ireland

2. KTH Royal Institute of Technology Department of Chemical Engineering 10044 Stockholm Sweden

Abstract

AbstractThe early stages of the molecular self‐assembly pathway leading to crystal nucleation have a significant influence on the properties and purity of organic materials. This mini review collates the work on organic mesoscale clusters and discusses their importance in nucleation processes, with a particular focus on their critical properties and susceptibility to sample treatment parameters. This is accomplished by a review of detection methods, including dynamic light scattering, nanoparticle tracking analysis, small angle X‐ray scattering, and transmission electron microscopy. Considering the challenges associated with crystallisation of flexible and large‐molecule active pharmaceutical ingredients, the dynamic nature of mesoscale clusters has the potential to expand the discovery of novel crystal forms. By collating literature on mesoscale clusters for organic molecules, a more comprehensive understanding of their role in nucleation will evolve and can guide further research efforts.

Funder

Irish Research Council

Science Foundation Ireland

Vetenskapsrådet

Publisher

Wiley

Subject

General Medicine

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