Affiliation:
1. Department of Chemistry Chemistry Research Laboratory Department of Chemistry University of Oxford 12 Mansfield Road Oxford OX1 3TA UK
Abstract
AbstractComplex cyclobutanes are important motifs in both bioactive molecules and natural products, yet their enantioselective preparation has not been widely explored. In this work, we describe rhodium‐catalyzed enantioselective additions of aryl and vinyl boronic acids to cyclobutenone ketals. This transformation involves enantioselective carbometalation to give cyclobutyl‐rhodium intermediates, followed by β‐oxygen elimination to afford enantioenriched enol ethers. Overall, this addition serves as a surrogate for Rh‐catalyzed 1,4‐additions to cyclobutenone.
Funder
Engineering and Physical Sciences Research Council
Fonds National de la Recherche Luxembourg