From Microbial Succinic Acid Production to Polybutylene Bio‐Succinate Synthesis

Author:

Tenhaef Niklas12,Hermann Alina23,Müller Moritz Fabian12,Görtz Jonas24,Marienhagen Jan125,Oldiges Marco125,Wiechert Wolfgang126,Bott Michael12,Jupke Andreas24,Hartmann Laura27,Herres-Pawlis Sonja23,Noack Stephan12ORCID

Affiliation:

1. Forschungszentrum Jülich GmbH Institute of Bio- and Geosciences, IBG-1: Biotechnology 52425 Jülich Germany

2. Forschungszentrum Jülich GmbH Bioeconomy Science Center (BioSC) 52425 Jülich Germany

3. RWTH Aachen University Institute of Inorganic Chemistry 52074 Aachen Germany

4. RWTH Aachen University Aachener Verfahrenstechnik – Fluid Process Engineering (AVT.FVT) 52074 Aachen Germany

5. RWTH Aachen University Institute of Biotechnology Worringer Weg 3 52074 Aachen Germany

6. RWTH Aachen University Computational Systems Biotechnology (AVT.CSB) 52074 Aachen Germany

7. Heinrich Heine University Düsseldorf Institute of Organic and Macromolecular Chemistry 40225 Düsseldorf Germany

Abstract

AbstractA simplified and scalable one‐pot process for the anaerobic production of succinic acid using a metabolically engineered Corynebacterium glutamicum strain is demonstrated. With targeted bioprocess optimization, succinic acid titer of 78 g L−1 and yield of 1.41 molSAmolGLC−1 were achieved. Succinic acid was recovered from the neutral fermentation broth by electrochemically induced crystallization and applied for polybutylene bio‐succinate synthesis using a biocompatible zinc catalyst. Except for a slight color change, the final biopolymer was comparable to the polymer from commercial precursors.

Funder

Bundesministerium für Bildung und Forschung

Publisher

Wiley

Subject

Industrial and Manufacturing Engineering,General Chemical Engineering,General Chemistry

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