Binding to dipeptidyl peptidase-4 determines the disposition of linagliptin (BI 1356) - investigations in DPP-4 deficient and wildtype rats

Author:

Retlich Silke,Withopf Barbara,Greischel Andreas,Staab Alexander,Jaehde Ulrich,Fuchs Holger

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference25 articles.

1. 3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors;Eckhardt;Bioorg Med Chem Lett,2008

2. Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV;Lambeir;Crit Rev Clin Lab Sci,2003

3. Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations;Nauck;J Clin Endocrinol Metab,1993

4. Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach;Orskov;Endocrinology,1988

5. Glucagonostatic and insulinotropic action of glucagon-like peptide I-(7-36)-amide;Komatsu;Diabetes,1989

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