Affiliation:
1. Department of Chemistry Iran University of Science and Technology Tehran Iran
2. School of Medicine Tehran University of Medical Sciences Tehran Iran
3. Undergraduate Program in Neuroscience University of British Columbia Vancouver British Columbia Canada
4. Gene, Cell & Tissue Research Institute Tehran University of Medical Science Tehran Iran
5. Clinical Research Development Center Qom University of Medical Sciences Qom Iran
Abstract
AbstractIntroductionVitamin C (ascorbic acid) is a water‐soluble vitamin, that plays a key role in the prevention and treatment of scurvy. As vitamin C is an antioxidant and thyroid function may be affected and may affect vitamin C levels, for the first time, we aimed to provide a detailed review of all human studies evaluating the different roles of vitamin C in the thyroid gland. Thyroid cancers, goitre, Graves' disease and other causes of hyperthyroidism and hypothyroidism were the conditions discussed in this study. Furthermore, vitamin C addition to other medications such as levothyroxine was also reviewed.MethodsIn this study, we reviewed the relevant literature regarding the association between vitamin C and thyroid diseases using original studies from PubMed, Scopus, Embase, and Web of Science.ResultsIn this review, we found anti‐cancer effects for intravenous (IV) administration of vitamin C in addition to the beneficial effects of using it in combination with radiotherapy and chemotherapy. As autoimmune diseases affect some antioxidant markers, some studies reported a significant difference in blood vitamin C levels in patients with autoimmune thyroid diseases such as Graves' disease. Despite many studies evaluating the effects of IV administration of vitamin C in mentioned diseases, there is a lack of evidence for oral consumption of vitamin C.ConclusionsTo conclude, there is a lack of evidence, especially clinical trials, for the therapeutic effects of vitamin C on thyroid diseases; however, promising results were reported in some studies in the literature.
Subject
Endocrinology, Diabetes and Metabolism
Cited by
4 articles.
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