Affiliation:
1. Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China
2. State Key Laboratory of Pharmaceutical Biotechnology The University of Hong Kong Hong Kong China
3. Dr. Li Dak‐Sum Research Centre The University of Hong Kong Hong Kong China
4. Department of Chemistry Faculty of Science National University of Singapore Singapore Singapore
Abstract
AbstractProtein‐based drugs have shown unique advantages to treat various diseases in recent years. However, most protein therapeutics in clinical use are limited to extracellular targets with low delivery efficiency. To realize targeted protein delivery, a series of stimuli‐triggered nanoparticle formulations have been developed to improve delivery efficiency and reduce off‐target release. These smart nanoparticles are designed to release cargo proteins in response to either internal or external stimuli at pathological tissues. In this way, varieties of protein‐based drugs including antibodies, enzymes, and pro‐apoptotic proteins can be effectively delivered to desired sites for the treatment of cancer, inflammation, metabolic diseases, and so on with minimal side effects. In this review, recent advances in the design of stimuli‐triggered nanomedicine for targeted protein delivery in different biomedical applications will be discussed. A deeper understanding of these emerging strategies helps develop more efficient protein delivery systems for clinical use in the future.
Funder
National Natural Science Foundation of China