Affiliation:
1. Department of Nutrition, School of Public Health Shahid Sadoughi University of Medical Sciences Yazd Iran
2. Department of Medical Biotechnology, School of Medicine Shahid Sadoughi University of Medical Sciences and Health Services Yazd Iran
3. Yazd Cardiovascular Research Center, Non‐communicable Diseases Research Institute Shahid Sadoughi University of Medical Sciences Yazd Iran
Abstract
AbstractCell death and the efficient removal of dead cells are two basic mechanisms that maintain homeostasis in multicellular organisms. efferocytosis, which includes four steps recruitment, recognition, binding and signaling, and engulfment. Effectively and quickly removes apoptotic cells from the body. Any alteration in efferocytosis can lead to several diseases, including autoimmune and inflammatory conditions, atherosclerosis, and cancer. A wide range of dietary components affects apoptosis and, subsequently, efferocytosis. Some vitamins, including fat‐soluble vitamins, affect different stages of efferocytosis. Among other things, by affecting macrophages, they are effective in the apoptotic cleansing of cells. Also, polyphenols indirectly intervene in efferocytosis through their effect on apoptosis. Considering that there are limited articles on the effect of nutrition on efferocytosis, in this article we will examine the effect of some dietary components on efferocytosis.