Exposure to 4,4′‐<scp>DDE</scp> in visceral adipose tissue and weight loss in adolescents from the <scp>Teen‐LABS</scp> cohort-Reference-Cited by-同舟云学术

Exposure to 4,4′‐DDE in visceral adipose tissue and weight loss in adolescents from the Teen‐LABS cohort

Published:2024-03-22 Issue:5 Volume:32 Page:1023-1032
ISSN:1930-7381
Container-title:Obesity
language:en
Short-container-title:Obesity

Author:

Rubbo Bruna¹,Li Zhenjiang¹^ORCID,Tachachartvanich Phum²³,Baumert Brittney O.¹,Wang Hongxu¹,Pan Shudi¹,Rock Sarah¹,Ryder Justin R.⁴,Jenkins Todd⁵,Sisley Stephanie⁶,Lin Xiangping⁷,Bartell Scott⁸,Inge Thomas H.⁴^ORCID,Xanthakos Stavra⁹,McNeil Brooklynn¹⁰,Robuck Anna R.⁷,La Merrill Michele A.²,Walker Douglas I.¹¹,Conti David V.¹,McConnell Rob¹,Eckel Sandrah P.¹,Chatzi Lida¹

Affiliation:

1. Department of Population and Public Health Sciences, Keck School of Medicine University of Southern California Los Angeles California USA

2. Department of Environmental Toxicology University of California Davis California USA

3. Laboratory of Environmental Toxicology Chulabhorn Research Institute Bangkok Thailand

4. Department of Surgery Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA

5. Division of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA

6. USDA/ARS Children's Nutrition Research Center, Department of Pediatrics Baylor College of Medicine Houston Texas USA

7. Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount Sinai New York New York USA

8. Department of Environmental and Occupational Health and Department of Statistics University of California Irvine California USA

9. Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA

10. Irving Institute for Clinical and Translational Research Columbia University New York New York USA

11. Gangarosa Department of Environmental Health Emory University Atlanta Georgia USA

Abstract

AbstractObjectiveDichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integrative translational approach of epidemiological analysis among adolescents with obesity and in vitro measures exploring the impact of DDE on adipogenesis via preadipocytes.MethodsWe included 63 participants from the Teen‐Longitudinal Assessment of Bariatric Surgery (Teen‐LABS) cohort. We assessed 4,4′‐DDE in visceral adipose tissue at surgery and BMI and waist circumference at surgery and 0.5, 1, 3, and 5 years after. We conducted longitudinal analysis to estimate the interaction on weight loss between DDE and time since surgery. In vitro analysis quantified adipogenic differentiation in commercial human preadipocytes exposed to 4,4′‐DDE via fluorescent staining and imaging.ResultsA dose–response relationship was observed, with the low‐exposure group having a greater reduction in BMI during the first year compared to higher‐exposure groups and showing smaller regains compared to higher‐exposure groups after the first year. In vitro analysis of preadipocytes treated with 4,4′‐DDE during adipogenic differentiation for 12 days showed a concentration‐dependent increase in lipid accumulation.ConclusionsDDE could contribute to weight trajectory among adolescents undergoing bariatric surgery, potentially mediated via promoted adipogenesis in preadipocytes.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Environmental Health Sciences

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/oby.24009

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